Fluorescence microscopy is widely used in various fields. Fluorescence microscopy is used to study the absorption, transportation, distribution and location of chemical substances in cells. Its use is mainly concentrated in three aspects from the perspective of industry: one is biological science microscopy, two is industrial microscopy, and three is medical microscopy. Therefore, the downstream industry of fluorescence microscope industry is mainly biological science industry, industry and medical industry.
Technology development is progressing rapidly
In May 2017, Peking University announced the successful development of a new generation of miniaturized two-photon fluorescence microscopy. It is reported that the new-generation miniature two-photon fluorescence microscopy weighs only 2.2 grams, the transverse resolution can reach 0.65 micron, the imaging quality is comparable with the commercial large desktop two-photon fluorescence microscopy. The imaging frame frequency has reached 40HZ (256*256 pixels) by adopting dual-axis symmetric high-speed microelectromechanical system rotoscope scanning technology, and it has the ability of multi-region random scanning and 10,000 lines per second line scanning.
Miniaturization two-photon fluorescence microscopic imaging changes the animals in the free way, to observe the cellular and subcellular structure can be used in animal feed, lactation, platform, fight, play, sleep and other natural behavior conditions, after or before study, learning and learning, long range observation of synapses, neurons, neural network, the remote connection areas of the brain, multi-scale and multi-level dynamic change.
The related results were published online on May 29, 2017 in the Nature Methods and Protocol Exchange, and a number of patents have been applied.
From 2008 to 2016, the number of fluorescence microscope-related patent applications in China showed an increasing trend. In 2008, the number of patent applications related to fluorescence microscopy in China was 59. By 2016, the number of fluorescence microscope-related patent applications in China reached a peak of 170 in recent years, up 188.1 percent from 2008. It can be seen that the development of fluorescence microscopy in China is progressing rapidly.
Up to now, from the perspective of fluorescence microscope-related patent applicants, the top patent applications are tsinghua university (26), northwest agriculture and forestry university (24), southeast university (22), wuhan university (19), zhejiang university (18), etc. It can be seen that the research and exploration of fluorescence microscopy in universities has undoubtedly become a major force in the field of fluorescence microscopy in China.
The market size keeps expanding
It is estimated that the market size of China's fluorescence microscope industry was 850 million yuan in 2011, and increased to 2.6 billion yuan in 2015, with the annual average growth rate reaching 28.5 percent. It can be seen that, with the national attention to the development of the instrument industry, as well as the upgrading of the technology and the gradual establishment of the brand on the fluorescence microscope in China, the market size of the fluorescence microscope industry is constantly expanding.
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